Therapeutic Carbohydrate Reduction for Lipedema: Guidelines for a Patient-Centered, Holistic Approach
Abstract
Lipedema is a chronic, often misdiagnosed disease characterized by painful, disproportionate
fat accumulation in the extremities. Commonly mistaken for obesity or lymphedema,
lipedema primarily affects women and has long been thought to be resistant to dietary
intervention, a belief originating from its initial description by Allen and Hines at the Mayo
Clinic in 1940. However, emerging research challenges this notion, revealing that individuals
with lipedema often respond positively to therapeutic carbohydrate (CHO) reduction,
particularly ketogenic diets (KD). Effective management of lipedema requires a
comprehensive, holistic approach.
